Stroke Volume Variation Directed Versus Conventional Fluid Therapy for Postoperative Acute Kidney Injury after Percutaneous Nephrolithotomy - A Randomized Pilot Study

Background: Percutaneous nephrolithotomy (PCNL) surgery may be associated with postoperative Acute Kidney Injury (AKI). Commonest intraoperative risk factors for AKI include hypotension and hypoperfusion. Intravenous fluids are administered during to optimize intravascular status thus prevent hypotension. Conventionally, intravenous using pre-calculated volumes based on maintenance needs. Alternatively, goal-directed fluid therapy Stroke Volume Variation (SVV) can used decide the volume of fluids. We compared early following use conventional (group C, n=15) versus SVV directed S, n = 17) in patients undergoing PCNL surgery. Methods: This double-blinded pilot study involved 32 adult patients, randomised two groups according type C or group S). Postoperative was diagnosed as per KDIGO guidelines. Results: Incidence clinically higher though statistically similar, (47.1% 26.7%) (P 0.234). increase eGFR, 24-hour urine output were greater S > 0.05). infused significantly lesser 0.000). The incidence requirement vasopressor maintain blood pressure lesser, similar 0.659). Conclusions: There appears a clinical trend guided despite better hemodynamic stability improvement eGFR first day. Keywords: nephrolithotomy, kidney injury, Fluid therapy, General anesthesia, Blood